EFFECT OF ALCOHOL INTOXICATIONS ON HEMATOLOGICAL PARAMETERS IN LOWER ANIMAL
Gin, though was blamed for various social problems, and it may have been a factor in the high death rates stabilized in London’s previously growing population.
Because gin as an alcohol is cheap and easy to access, people especially the poor embrace it and become intoxicated with the drink. This excessive consumption is a common cause of hospital admission throughout the western world. (Lieber, 1995). An alcoholic is a person who consumes an amount of alcohol capable of producing pathological changes.
The amount of alcohol capable of producing disease depends on a variety of factors, including genetic predisposition, malnutrition and concomitant viral infections of the liver.
It was reported that all cause increase mortality rate, and the rates are lower for moderate drinkers than for non-drinkers because of a lower lower rate ofs heart disease.
This beneficial effect of moderate alcohol consumption or ALCOHOL INTOXICATIONS might be explained by a rise of high density lipoprotein cholesterol (HDL) induced by alcohol consumption.
Acute or chronic alcohol consumption cause degeneration in different internal organs and systems of adults. (Watabiri et al., 1999). Important functional disorders of these organs and systems occur frequently because of these negative effects, it was stated that high alcohol intake is a known cause of diarrhea, other gastro-intestinal symptoms and in advanced states decrease in body weight.
Generally, it is accepted that, in individuals with high alcohol consumption, malnutrition develops depending on the possible changes in intestinal absorption mechanisms and dysfunction of some organs such as the liver and the pancreas.
An evaluation of the effects of alcoholic intoxication on the haematological indices in the blood of wistar albino rats would be investigated to proffer good understanding of the cause of the increase in the size of red cells and the percentage of alcohol that will induce changes in hematological indices.
Purpose of the Research
Alcohol abuse is known to have a wide array of adverse effects on blood cell formation, but the mechanisms underlying such effects remain unclear. Many of the toxic effects of ethanol have been attributed to its toxic metabolite (acetaldehyde). The aim of the present research is as follows:
- To examine the effects of ethanol and acetaldehyde in creating abnormalities in blood cell indices.
- To evaluate the dose of alcohol that would induce changes in hematological indices
- To explore the relationship between ethanol consumption and laboratory findings in albino wistar rats.