GENETIC FACTORS INFLUENCING ADAPTIVE IMMUNITY
Humoral and cell-mediated immune responses limit malaria parasite multiplication, and many cytokines contributes to the pathogenesis of malaria as well as to the resolution of infections (Schofield and Grau, 2005).
It is not surprising that genetic studies have identified several loci correlated with the severity of malaria (Frodsham and hill 2004). For example, polymorphisms at the HLA loci, which course of malaria. In West Africa an HLA class I antigen (HLA Bw53) and an HLA class II haplotype are independently associated with protection against severe malaria.
However, HLA correlations vary, depending on the genetic constitution of the polymorphic malaria parasite, which differs in different geographic locations (Frodsham and Hill, 2004).