Platelets: BRIEF HISTORY- From antiquity to the 1800s, salicylates from plants sources (white willow, Salix alba) provided a folk remedy for pain and fever. In the mid-1800s, salicylic acid was synthesized in Europe, followed shortly thereafter by the synthesis of acetyl-salicylic.
The Bayer Company developed acetyl-salicylic acid (ASA) as a commercial pharmaceutical product and trademarked the compound as aspirin. Aspirin is now widely accepted as a treatment for headache and musculo-skeletal pain as implied in a doctor’s well-worn suggestion: “Take two aspirin and call me in the morning”.
Platelets And its study
For example, average yearly consumption of aspirin in developed countries in 1985 approximated 100 tablets per person, (Arrowsmith, et al, 1987.). A variety of aspirin like agents are available referred to as non-steroidal anti-inflammatory drugs (NSAIDS). Several forms of NSAIDS, including aspirin, are shown below.
A. Salicylates B. Para-aminophenols
A. salicylates: Salicylic acid and acetyl-salicylic (ASA; trademark: Aspirin, Bufferin, Allke-seltzer). B. Para-aminophenols:acetaminophen (trademarks: Tylenol). C. Non salicylates aspirin-like drugs: Ibuprofen (trademarks: Advil, Motrin, Nuprin).
Vasoprine (brand name; Vasodilan), is used along with other treatment for certain blood vessel diseases (e.g., arteriosclerosis obliterans, Raynaud’s disease, Buerger’s disease, cerebrovascular insufficiency). It works by widening blood vessel to help increase blood flow (improve circulation) to certain parts of the body (e.g., hands, feet, brain). This effect may help to decrease symptoms such as cold hands and feet, numbness, tingling, and decreased memory or judgment.
This medication is taken by mouth with or without food, usually 3 to 4 times daily or as directed by your doctor. This is used regularly to get the most benefit from it.
- Platelets: Flow Cytometry- Platelets can be evaluated for functional defects using flow cytometry. This test uses lasers to determine proteins that are present on the
platelets surface and how they
- PLATELET ADHESION AND ACTIVATION, PLATELET RELEASE REACTION: Following blood vessel injury, platelets adhere to the exposed subendothelial connective tissues. Subendothelial microfibrils bind the larger multi-members of
VWF which bind to platelet membrane 1b complex.