In the study on the in-vitro-helicobacter pylori activity of extract of selected medicinal plants from south west Nigeria, the methanol of the dried whole plant of Emilia coccinea at 200mg cm3 was found to be weakly active agaist the isolated (ndipet at 2007 in another study on the antimicrobial activity of the leaf of extract of Emilia coccinea, it was observed that at 5mg c.m3 concentration, the aqueous extract did not have any antimicrobial activity on the microorganisms tested but the methanol extract was most active agaist e.coli .
There was no activity agaist C.albicans (teke et al,the report of a study on the fungicidal effects on conidial germination and mycelia growth of corynespore casslicola showed that the aqueous leaf extract of E. coccinea exhibited 25% inhibition while ocimum bosillicum exhibited 100% (ogberbor and adekunle) 2005).
The solution of the fractions of E-coccinea used for the antimicrobial screening in our study were 125mg cm3 for the ethyl acetate fraction and 74mg cm3 for the butanol fraction the study by ndip et at (2007) was on whole plant and the 200mgcm-3 of solution .A Oghehor and Adekenle (2005) is in agreement with the potent activity of the ethyl acetate extract of E.coccinea of the activity agaist S.aureus was about the same as these exhibited by E.coccinea. and the ciprofloxacin control. Activity agaist c.albicans was same as that exhibited by e.coccinea the other microorganism was less than of E.coccinea.
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The ethyl acetate fraction exhibited significant antimicrobial activity agaist E-coli, k pneumonia and S. aureus the batanol fraction of E-coccinea also exhibited potent antibacterial activity of about the same magnitude as ciropfloxacin against B subtillis E, faecalis and S. aureus ATcc 2593.
The activity against E-coli Atcc 25922, K pneumoniae, E-coli P. aeruginosa, Solmonella spp. S. typhimurium shigella flexneril S. aureus and S. albus were of lower magnitude than that ofciprofloxacin. This significant both the ethyl acetate and butanol fraction from the leaves of E-coccinea show potent antimicrobial activity with the ethyl acetate fraction exhibiting greater potency. the extract of the leaves of E-coccinea also helps in the management of veneral diseases, abscesses and eye diseases (Odugbem, 2006 et al., 2008).
The antimicrobial activity of both the ethyl acetate and butanol factions of the leaf extract of E-coccinea can be used to support some of the ethnomedical uses of the plant. In Nigeria the leaves are chewed to treat diarrhoea stomach ache, bowel and bladder disorder (Teke et al., 2007).
The major causative organism of diarrheoea in human include e,albicans E-coli S. typhimurium, S-flexneril and S. typhimarium and s. flexnerii are inhibited by the butanol fraction and S. aureus is inhibited by both fraction S. the leaves extract of E.coccinea should function as an antidarrhoeal phytomedicine. Teke et al., 2007) reported that the methanol extract of E-coccinea leaves shawed antimicrobial activities on some gastrointestinal microorganism thus providing scientific support for the anti-diorrheal activity.
The ethyl acetate fraction of dependens would also exhibit some measure of anti-diarhoeal activity though not as potent as E-coccincea because it also exhibited bioactivity against C.albicans, E-coli and S. aureus.
The butanol fraction from the stem of E-depends was found to be active against only two of the microorganism namely E-faecalis and S. aureus ATcc 25923. The butanol fraction of C-australis exhibited activity against only three of the microorganisms tested these are B. Subtitles, E faecalis ad P-aeruginosa S. aureus has been isolated from wounds and eye infections.
Adelowotan et al., 2008 and the ethyl acetate fractions the plants were found to be active against a strain of this microorganism hence this may constitute scientific support for the use of the plants in treating eye infections and the use of australises for the management of sore and the E.coceinea for the management of abscesses of the breast