All individuals participating in sports, whether or not they have sickle cell trait should have adequate hydration before during and after exertion in hot condition and also by avoidance of excessive fluid loss in grade exercise.
Individuals with hematuria should actively hydrate themselves before and after physical exertion. Individuals who have frequent, severe or persistent hematuria may need to avoid activities that regularly cause episodes. Hydration and bed rest may abort episodes if done immediately. (Baldree, et al, 2009).
- Educate the carrier about the nature of sickle cell trait.
- Provide counseling of the risk of having children with sickle cell Hb disorders.
- Patients with hematuria should be monitor their fluid intake and output carefully, if fluid or sodium retention develops the doctor should order diuretics.
- Tell carriers to use caution during very strenuous exercise in hot weather or at high altitude.
Malaria and sickle cell are still major challenges to infections disease medicine and to hematology respectively and both are also major public health problems. One might have hoped that what we have learnt about the advantage of AS heterozygotes with respect to malaria would enable us to protect from malaria mortality.
Malaria resistance by the sickle cell trait (genotype HbAS) has served as the prime example of genetic selection for ever half a century. Nevertheless, the mechanism of this resistance remains the subject of considerable debate. While it probably involves innate factors such as the reduced ability of plasmodium falciparum parasites to grow and multiply in HbAS erythrocytes recent observations suggest that it might also involve the accelerated acquisition of malaria-specific immunity. Malaria protection by HbAS involves the enhancement of not only innate but also of acquired immunity to the parasite.
Parents and their families should be counsel about their risk of having a child with sickle cell disease based on their parttners genotype. Both structural hemoglobin variants and beta thalassemia need to be excluded before providing such education.
Individuals with hematuria should be educated about the benign nature of hematuria in sickle cell trait, preventive measures and avoidance of precipitating activities need to be stressed in the rare individuals with persistent episodes.